ALL PUBLICATIONS

Joshi lab publications:

Primary Literature:

Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis. J Immunother Cancer. 2023 Aug;11(8):e007358. doi: 10.1136/jitc-2023-007358. PMID: 37586769; PMCID: PMC10432652.

Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn HN, Sefik E, Cheung JF, Hornick NI, Aizenbud L, Joshi NS, Kluger H, Iwasaki A, Bosenberg MW, Flavell RA. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2304319120. doi: 10.1073/pnas.2304319120. Epub 2023 Jul 17. PMID: 37459511; PMCID: PMC10372654.

Damo M, Hornick NI, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza JL, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky WE, Leventhal JS, Krishnaswamy S, Joshi NS. PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens. Nature. 2023 Jul;619(7968):151-159. doi: 10.1038/s41586-023-06217-y. Epub 2023 Jun 21. PMID: 37344588.

Kasmani MY, Zander R, Chung HK, Chen Y, Khatun A, Damo M, Topchyan P, Johnson KE, Levashova D, Burns R, Lorenz UM, Tarakanova VL, Joshi NS, Kaech SM, Cui W. Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection. J Exp Med. 2023 Jan 2;220(1):e20220679. doi: 10.1084/jem.20220679. Epub 2022 Oct 31. PMID: 36315049; PMCID: PMC9623343.

Cui C, Wang J, Fagerberg E, Chen PM, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H, Craft J, Joshi NS*. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell. 2021 Dec 9;184(25):6101-6118.e13. doi: 10.1016/j.cell.2021.11.007. Epub 2021 Nov 30. PMID: 34852236; PMCID: PMC8671355.

Fitzgerald B, Connolly KA, Cui C, Fagerberg E, Mariuzza DL, Hornick NI, Foster GG, William I, Cheung JF, Joshi NS. A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma. Cell Rep Methods. 2021 Sep 27;1(5):100080. doi: 10.1016/j.crmeth.2021.100080. Epub 2021 Sep 16. PMID: 34632444; PMCID: PMC8500377

Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS. A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response. Sci Immunol. 2021 Oct;6(64):eabg7836. doi: 10.1126/sciimmunol.abg7836. Epub 2021 Sep 2. PMID: 34597124; PMCID: PMC8593910.

Damo M*, Fitzgerald B*, Lu Y, Nader M, William I, Cheung JF, Connolly KA, Foster GG, Akama-Garren E, Lee DY, Chang GP, Gocheva V, Schmidt LM, Boileve A, Wilson JH, Cui C, Monroy I, Gokare P, Cabeceiras P, Jacks T, Joshi NS. Inducible de novo expression of neoantigens in tumor cells and mice. Nat Biotechnol. 2021 Jan;39(1):64-73. doi: 10.1038/s41587-020-0613-1. Epub 2020 Jul 27. PMID: 32719479; PMCID: PMC7854852.

George J, Bajaj D, Sankaramangalam K, Yoo JW, Joshi NS, Gettinger S, Price C, Farrell JJ. Incidence of pancreatitis with the use of immune checkpoint inhibitors (ICI) in advanced cancers: A systematic review and meta-analysis.Pancreatology. 2019 Jun;19(4):587-594. doi: 10.1016/j.pan.2019.04.015. Epub 2019 May 2.PMID: 31076344

Reviews:

Cui C, Craft J, Joshi NS. T follicular helper cells in cancer, tertiary lymphoid structures, and beyond. Semin Immunol. 2023 Sep;69:101797. doi: 10.1016/j.smim.2023.101797. Epub 2023 Jun 19. PMID: 37343412.

Connolly KA, Fitzgerald B, Damo M, Joshi NS. Novel Mouse Models for Cancer Immunology. Annu Rev Cancer Biol. 2022 Apr;6(1):269-291. doi: 10.1146/annurev-cancerbio-070620-105523. Epub 2022 Jan 18. PMID: 36875867; PMCID: PMC9979244.

Commentaries:

Joshi NS, Delgoffe GM. Editorial: Perspectives on the landscape of immunology from Nikhil Joshi. Immunology. 2022 Apr;165(4):369-370. doi: 10.1111/imm.13467. PMID: 35301723.

Damo M, Joshi NS. Treg cell IL-10 and IL-35 exhaust CD8+ T cells in tumors. Nat Immunol. 2019 Jun;20(6):674-675. doi: 10.1038/s41590-019-0389-y.PMID: 31011189 

Connolly KA, Fitzgerald B, Joshi NS. Lineage Specifiers in Lung Cancer Are Ahead of Their TIME. Immunity. 2018 Oct 16;49(4):587-589. doi: 10.1016/j.immuni.2018.10.004.PMID: 30332625

Nikhil Joshi publications:

Schmidt L, Eskiocak B, Kohn R, Dang C, Joshi NS, DuPage M, Lee DY, Jacks T. Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17460-17469. doi: 10.1073/pnas.1904253116. Epub 2019 Aug 13. PMID: 31409707

Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. 2017 May 18;545(7654):355-359. PubMed PMID: 28489818.

Xin G, Schauder DM, Jing W, Jiang A, Joshi NS, et al. Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):740-745. PubMed PMID: 28069963; PubMed Central PMCID: PMC5278465.

Akama-Garren EH*, Joshi NS*, Tammela T, Chang GP, Wagner BL, et al. A Modular Assembly Platform for Rapid Generation of DNA Constructs. Sci Rep. 2016 Feb 18;6:16836. PubMed PMID: 26887506; PubMed Central PMCID: PMC4757859.

Dominguez CX, Amezquita RA, Guan T, Marshall HD, Joshi NS, et al. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med. 2015 Nov 16;212(12):2041-56. PubMed PMID: 26503446; PubMed Central PMCID: PMC4647261.

Joshi NS, Akama-Garren EH, Lu Y, Lee DY, Chang GP, et al. Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses. Immunity. 2015 Sep 15;43(3):579-90. PubMed PMID: 26341400; NIHMSID: NIHMS769682; PubMed Central PMCID: PMC4826619. 

Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, et al. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature. 2014 Dec 18;516(7531):428-31. PubMed PMID: 25337879; NIHMSID: NIHMS633102; PubMed Central PMCID: PMC4292871.

Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, et al. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014 Oct 16;514(7522):380-4. PubMed PMID: 25119044; NIHMSID: NIHMS606316; PubMed Central PMCID: PMC4199937.

Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, et al. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. J Immunol. 2014 May 1;192(9):4221-32. PubMed PMID: 24659688; NIHMSID: NIHMS570384; PubMed Central PMCID: PMC4071140.

Drake A, Joshi NS, Szeto GL, Zhu E, Eisen HN, et al. Koch Institute Symposium on Cancer Immunology and Immunotherapy. Cancer Immunol Res. 2013 Oct;1:217-222. PubMed PMID: 24466562; NIHMSID: NIHMS525722; PubMed Central PMCID: PMC3897860.

Joshi NS, Jacks T. Immunology Guilty by association. Science. 2013 Mar 8;339(6124):1160-1. PubMed PMID: 23471395.

Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, et al. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J Immunol. 2011 Oct 15;187(8):4068-76. PubMed PMID: 21930973; NIHMSID: NIHMS319679; PubMed Central PMCID: PMC3991478. 

Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol. 2010 Nov 1;185(9):5315-25. PubMed PMID: 20921525; NIHMSID: NIHMS343065; PubMed Central PMCID: PMC4267692.

Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, et al. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16601-6. PubMed PMID: 20823247; PubMed Central PMCID: PMC2944719.

Hinson ER*, Joshi NS*, Chen JH, Rahner C, Jung YW, et al. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2010 May 15;184(10):5723-31. PubMed PMID: 20410488; NIHMSID: NIHMS526962; PubMed Central PMCID: PMC3883313.

Cui W, Joshi NS, Jiang A, Kaech SM. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine. 2009 Mar 26;27(15):2177-87. PubMed PMID: 19201385; NIHMSID: NIHMS103971; PubMed Central PMCID: PMC2803112.

Chandele A, Joshi NS, Zhu J, Paul WE, Leonard WJ, et al. Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol. 2008 Apr 15;180(8):5309-19. PubMed PMID: 18390712; NIHMSID: NIHMS144818; PubMed Central PMCID: PMC2792750.

Joshi NS, Kaech SM. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. J Immunol. 2008 Feb 1;180(3):1309-15. PubMed PMID: 18209024.

Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, et al. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug;27(2):281-95. PubMed PMID: 17723218; NIHMSID: NIHMS29566; PubMed Central PMCID: PMC2034442. 

Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, et al. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006 Dec;5(6):473-86. PubMed PMID: 17129212.

Martomo SA, Fu D, Yang WW, Joshi NS, Gearhart PJ. Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase. J Immunol. 2005 Jun 15;174(12):7787-91. PubMed PMID: 15944282.

Henry RM, Hoppe AD, Joshi N, Swanson JA. The uniformity of phagosome maturation in macrophages. J Cell Biol. 2004 Jan 19;164(2):185-94. PubMed PMID: 14718518; PubMed Central PMCID: PMC2172341.